TLR-3

CAT: 0209-100-360-L1000Size: 5x 200 µgDry Ice: NoHazardous: No
CAT#:0209-100-360-L1000Size:5x 200 µg
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Description
TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL) -1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.
Synonyms
TLR3; CD283; IIAE2
NCBI Gene ID
7098
UniProt
O15455
Accession Number
NP_003256.1
Accession Number mRNA
NM_003265
Chromosomal Location
4q35
Reactivity
Human
Cross Reactivity
Human
Sequence
STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r) . The ED50for this effect is ≤ 30 μg/ml in the presence of 100 μg/ml of Poly I:C.
Length
681
Form
Lyophilized
Molecular Weight
77.4 kDa
Host or Source
HEK 293 cells

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MBS6502909-01TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (HRP)
MBS6502905-01TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (AP)
MBS6249369-01TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (Biotin)
T8050-20N-PETLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (PE)
T8050-20N-APCTLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (APC)
MBS6502908-01TLR3 (Toll Like Receptor 3, Toll-like Receptor 3, TLR 3, TLR-3, CD283, CD283 Antigen) (FITC)

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