Relaxin-3

CAT: 0209-100-356-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-100-356-L500Size:500 µg
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Description
Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.
Synonyms
RLN3; H3; RXN3; ZINS4; insl7
NCBI Gene ID
117579
UniProt
Q8WXF3
Accession Number
NP_543140.1
Accession Number mRNA
NM_080864
Chromosomal Location
19p13.2
Reactivity
Human
Cross Reactivity
Human
Sequence
A-chain: DVLAGLSSS CCKWGCSKSE ISSLC; B-chain: RAAPYGVRL CGREFIRAVI FTCGGSRW
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
51
Form
Lyophilized
Molecular Weight
5.5 kDa
Host or Source
E. coli

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