NT-3

• Description:

  NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues) . Human and Mouse NT-3 sequences are identical

• Synonyms:

  NTF3; NT3; HDNF; NGF2; NGF-2

• NCBI Gene ID:

  4908

• UniProt:

  P20783

• Accession Number:

  NP_001096124.1

• Accession Number mRNA:

  NM_001102654

• Chromosomal Location:

  12p13

• Reactivity:

  Human

• Cross Reactivity:

  Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey

• Sequence:

  MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

• Length:

  120

• Form:

  Lyophilized

• Molecular Weight:

  13.6 kDa

• Host or Source:

  E. coli