PlGF-3

• Description:

  PlGF-3 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-3 is expressed exclusively in the placenta. It signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. PlGF-3 lacks heparin binding affinity. Recombinant human PlGF-3 is a 45.7 kDa disulfide-linked homodimeric protein of two 203 amino acid polypeptide chains.

• Synonyms:

  PlGF; placental growth factor

• NCBI Gene ID:

  5228

• UniProt:

  P49763-1

• Accession Number:

  NP_001193941.1

• Accession Number mRNA:

  NM_001207012.1

• Chromosomal Location:

  2p21-p16

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRHSPGRQS PDMPGDFRAD APSFLPPRRS LPMLFRMEWG CALTGSQSAV WPSSPVPEEI PRMHPGRNGK KQQRKPLREK MKPERCGDAV PRR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-50.0 ng/ml.

• Length:

  203

• Form:

  Lyophilized

• Molecular Weight:

  45,7 kDa

• Host or Source:

  E. coli