SCGF-alpha

• Description:

  Stem Cell Growth Factor-alpha (SCGF-alpha) is a newly discovered hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. Human SCGF-alpha is a non-glycosilated species-specific cytokine that can support growth of primitive hematopoietic cells, and in combination of EPO or GM-CSF, it promotes proliferation of erythroid and myeloid progenitors, respectively. Recombinant human SCGF-alpha is a 33.9 kDa polypeptide containing 305 amino acid residues.

• Synonyms:

  CLEC11A; P47; SCGF; LSLCL; CLECSF3

• NCBI Gene ID:

  6320

• UniProt:

  Q9Y240

• Accession Number:

  NP_002966.1

• Accession Number mRNA:

  NM_002975.2

• Chromosomal Location:

  19q13.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  GHGARGAERE WEGGWGGAQE EEREREALML KHLQEALGLP AGRGDENPAG TVEGKEDWEM EEDQGEEEEE EATPTPSSGP SPSPTPEDIV TYILGRLAGL DAGLHQLHVR LHALDTRVVE LTQGLRQLRN AAGDTRDAVQ ALQEAQGRAE REHGRLEGCL KGLRLGHKCF LLSRDFEAQA AAQARCTARG GSLAQPADRQ QMEALTRYLR AALAPYNWPV WLGVHDRRAE GLYLFENGQR VSFFAWHRSP RPELGAQPSA SPHPLSPDQP NGGTLENCVA QASDDGSWWD HDCQRRLYYV CEFPF

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its inhibitory effect on the proliferation of TF-1 cells previously grown in media containing GM-CSF. The ED50 for this effect was observed at 2.5 ng/ml.

• Length:

  305

• Form:

  Lyophilized

• Molecular Weight:

  33.9 kDa

• Host or Source:

  E. coli