SCGF alpha Recombinant Protein

The three mammalian isoforms of TGF-β , TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

6320

Q9Y240

NP_002966.1

Recombinant Proteins

Growth Factors, Immunology

Room Temp

The lyophilized SCGF alpha recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted SCGF alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing SCGF alpha recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

C-type lectin domain family 11, member A

Homo sapiens

P47, SCGF, LSLCL, CLECSF3, C-type lectin domain family 11 member A, C-type lectin superfamily member 3

Human

4506803