SCGF-beta

• Description :

  SCGF-α and -β are hematopoietic growth factor that exerts their activity at early stages of hematopoiesis. The SCGFs are non-glycosylated species-specific cytokines that can support growth of primitive hematopoietic cells, and in combination with EPO or GM-CSF, promote proliferation or erthroid or myeloid progenitors, respectively. Recombinant human SCGF-β is a 25.0 kDa polypeptide containing 227 amino acid residues.

• Synonyms :

  CLEC11A; P47; SCGF; LSLCL; CLECSF3

• NCBI Gene ID :

  6320

• UniProt :

  Q9Y240

• Accession Number :

  NP_002966.1

• Accession Number mRNA :

  NM_002975.2

• Chromosomal Location :

  19q13.3

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  MGHGARGAER EWEGGWGGAQ EEEREREALM LKHLQEALGL PAGRGDENPA GTVEGKEDWE MEEDQGEEEE EEATPTPSSG PSPSPTPEDI VTYILGRLAG LDAGLHQLHV RLHALDTRVV ELTQGLRQLR NAAGDTRDAV QALQEAQGRA EREHGRLEGC LKGLRLGHKC FLLSRDFEAQ PSASPHPLSP DQPNGGTLEN CVAQASDDGS WWDHDCQRRL YYVCEFPF

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells, previously grown in media containing GM-CSF. The expected ED50 for this effect is ≤ 7.0 ng/ml.

• Length :

  227

• Form :

  Lyophilized

• Molecular Weight :

  25.0 kDa

• Host or Source :

  E. coli