Lymphotoxin alpha

• Description :

  Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.

• Synonyms :

  LTA; LT; TNFB; TNFSF1

• NCBI Gene ID :

  4049

• UniProt :

  P01374

• Accession Number :

  NP_001153212.1

• Accession Number mRNA :

  NM_001159740.1

• Chromosomal Location :

  6p21.3

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Recombinant human Lymphotoxin alpha/beta

• Clone :

  (#12B4)

• Applications :

  N

• Purification Method :

  Protein G chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Mouse

• Isotype :

  IgG1