Lymphotoxin alpha

• Description:

  Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.

• Synonyms:

  LTA; LT; TNFB; TNFSF1

• NCBI Gene ID:

  4049

• UniProt:

  P01374

• Accession Number:

  NP_001153212.1

• Accession Number mRNA:

  NM_001159740.1

• Chromosomal Location:

  6p21.3

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human Lymphotoxin alpha/beta

• Clone:

  (#12B4)

• Applications:

  N

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1