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R-Spondin-2

CAT: 0209-100-426-L500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0209-100-426-L500Size:500 µg
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Description
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-2 is a 24.4 kDa protein consisting of 212 amino acid residues. Due to glycosylation, R-Spondin-2 migrates at an apparent molecular weight of approximately 30.0 kDa by SDS PAGE analysis under reducing conditions.
Synonyms
Roof plate-specific Spondin-2, RSPO2
NCBI Gene ID
340419
UniProt
Q6UXX9
Accession Number
NP_848660.3
Accession Number mRNA
NM_178565.4
Chromosomal Location
8q23.1
Reactivity
Human
Cross Reactivity
Human
Sequence
ASYVSNPICK GCLSCSKDNG CSRCQQKLFF FLRREGMRQY GECLHSCPSG YYGHRAPDMN RCARCRIENC DSCFSKDFCT KCKVGFYLHR GRCFDECPDG FAPLEETMEC VEGCEVGHWS EWGTCSRNNR TCGFKWGLET RTRQIVKKPV KDTILCPTIA ESRRCKMTMR HCPGGKRTPK AKEKRNKKKK RKLIERAQEQ HSVFLATDRA NQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
R-Spondin-2 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
Length
212
Form
Lyophilized
Molecular Weight
24.4 kDa
Host or Source
CHO cells

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