Products for Research Use Only
RegisterLogin

R-Spondin-1

CAT: 0209-M10-004Size: 20 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-M10-004Size:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant Murine R-Spondin-1 is a 27.1 kDa protein consisting of 245 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions.
Synonyms
Roof plate-specific Spondin-1, RSPO1
NCBI Gene ID
192199
UniProt
Q9Z132
Accession Number
NP_619624.2
Accession Number mRNA
NM_138683.2
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCQEGLYL HKGRCYPACP EGSTAANSTM ECGSPAQCEM SEWSPWGPCS KKRKLCGFRK GSEERTRRVL HAPGGDHTTC SDTKETRKCT VRRTPCPEGQ KRRKGGQGRR ENANRHPARK NSKEPGSNSR RHKGQQQPQP GTTGPLTSVG PTWAQ
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells.
Length
245
Form
Lyophilized
Buffer
10mM Sodium Phosphate, pH 7.5 and 150mM NaCl
Reconstitution
Water
Molecular Weight
40.0 kDa
Host or Source
CHO cells

UniProtKB · Q9Z132

R-spondin-1

RSPO1_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9Z132
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Rspo1
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q3V1S3
Protein keywords

PTM

Disulfide bondGlycoprotein

Molecular function

Heparin-binding

Cellular component

NucleusSecreted

Technical term

Reference proteome

Domain

RepeatSignal

Biological process

Sensory transductionWnt signaling pathway

Related Products

CatalogName
100-427R-Spondin-3
100-427-L500R-Spondin-3
100-426R-Spondin-2
100-427SR-Spondin-3
100-426SR-Spondin-2
100-427-L1000R-Spondin-3
100-426-L1000R-Spondin-2
100-426-L500R-Spondin-2
100-426-L250R-Spondin-2
100-426-L100R-Spondin-2

Alternative Products

CatalogName
MBS2889533R-spondin-1
331580-01R-spondin-1 (RSPO1)
491013RSPO1 (R-spondin-1)
549600R-Spondin 1 (Biotin)
142065R-Spondin 1 (RSPO1)
HC51245Human R-Spondin-1
E21-D83R-spondin-1/RSPO1
MBS692477-01Mouse R-Spondin-1
030582R-spondin1 (Roof plate-specific spondin-1, RSPO, R-spondin-1)
PH2041-.1Recombinant Human R-Spondin 1

Popular Products