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R-Spondin-3

CAT: 0209-100-427Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0209-100-427Size:20 µg
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Description
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.
Synonyms
PWTSR, THSD2, Roof plate-specific Spondin-3, RSPO3
NCBI Gene ID
84870
UniProt
Q9BXY4
Accession Number
NP_116173.2
Accession Number mRNA
NM_032784.4
Chromosomal Location
6q22.33
Reactivity
Human
Cross Reactivity
Human
Sequence
MHPNVSQGCQ GGCATCSDYN GCLSCKPRLF FALERIGMKQ IGVCLSSCPS GYYGTRYPDI NKCTKCKADC DTCFNKNFCT KCKSGFYLHL GKCLDNCPEG LEANNHTMEC VSIVHCEVSE WNPWSPCTKK GKTCGFKRGT ETRVREIIQH PSAKGNLCPP TNETRKCTVQ RKKCQKGERG KKGRERKRKK PNKGESKEAI PDSKSLESSK EIPEQRENKQ QQKKRKVQDK QKSVSVSTVH
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
R-Spondin-3 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
Length
240
Form
Lyophilized
Molecular Weight
26.9 kDa
Host or Source
CHO cells

UniProtKB · Q9BXY4

R-spondin-3

RSPO3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BXY4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RSPO3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RC27, Q5VTV4, Q96K87
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Molecular function

Heparin-binding

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignal

Cellular component

Secreted

Biological process

Sensory transductionWnt signaling pathway

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