Products for Research Use Only
RegisterLogin

R-Spondin-1

CAT: 0209-100-130Size: 20 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-100-130Size:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant human R-Spondin-1 is a 26.7 kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS PAGE analysis under reducing conditions.
Synonyms
Roof plate-specific Spondin, Rspo1
NCBI Gene ID
284654
UniProt
Q2MKA7
Accession Number
NP_001033722.1
Accession Number mRNA
NM_001038633.3
Reactivity
Human
Cross Reactivity
Human
Sequence
SRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSRRRKGQQQQQQQGTVGPLTSAGPA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
R-spondin-1 enhances BMP-2 mediated differentiation of MC3T3-E1 cells. The expected ED50 is 1.0-3.0 ug/ml.
Length
243
Form
Lyophilized
Molecular Weight
26.7 kDa
Host or Source
CHO cells

UniProtKB · Q2MKA7

R-spondin-1

RSPO1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q2MKA7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RSPO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2A420, Q0H8S6, Q14C72, Q5T0F2, Q8N7L5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Molecular function

Heparin-binding

Cellular component

NucleusSecreted

Disease

Palmoplantar keratoderma

Domain

RepeatSignal

Biological process

Sensory transductionWnt signaling pathway

Related Products

CatalogName
100-427-L500R-Spondin-3
100-427R-Spondin-3
100-427-L1000R-Spondin-3
100-426-L1000R-Spondin-2
100-426-L500R-Spondin-2
100-426-L250R-Spondin-2
100-426-L100R-Spondin-2
100-426R-Spondin-2
100-427SR-Spondin-3
100-426SR-Spondin-2

Alternative Products

CatalogName
MBS2889533R-spondin-1
549600R-Spondin 1 (Biotin)
331580-01R-spondin-1 (RSPO1)
491013RSPO1 (R-spondin-1)
152079R-Spondin 1 (RSPO1)
HC51245Human R-Spondin-1
E21-D83R-spondin-1/RSPO1
MBS692477-01Mouse R-Spondin-1
030582R-spondin1 (Roof plate-specific spondin-1, RSPO, R-spondin-1)
PH2041-.1Recombinant Human R-Spondin 1

Popular Products