PF-4 (CXCL4)

• Description :

  PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

• Synonyms :

  PF4; PF-4; CXCL4; SCYB4

• NCBI Gene ID :

  5196

• UniProt :

  P02776

• Accession Number :

  NP_002610.1

• Accession Number mRNA :

  NM_002619.2

• Chromosomal Location :

  4q12-q21

• Reactivity :

  Human

• Cross Reactivity :

  Mouse, Trout, Human, Bacteria

• Sequence :

  EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

• Length :

  70

• Form :

  Lyophilized

• Molecular Weight :

  7.8 kDa

• Host or Source :

  E. coli