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IL-4

CAT: 0209-M10-016-L50Size: 50 μgDry Ice: NoHazardous: No
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CAT#:0209-M10-016-L50Size:50 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1) . IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.
Synonyms
Il4; Il-4; BSF-1
NCBI Gene ID
16189
UniProt
P07750
Accession Number
NP_067258
Accession Number mRNA
NM_021283
Chromosomal Location
11 B1.3; 11 29.0 cM
Reactivity
Mouse
Cross Reactivity
Rat, Pig, Mouse, Human, Leech, Trout
Sequence
MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & Coomassie stain
Bioactivity
The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
Length
120
Form
Lyophilized
Molecular Weight
13.5 kDa
Host or Source
E. coli
N Terminal Sequence
MHIHG

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