I-TAC (CXCL11)

• Description:

  Human I-TAC (Interferon-inducible T cell alpha chemoacttractant) is an 8.3 kDa protein containing 73 amino acid residues. I-TAC is a novel non-ELR CXC chemokine. It is regulated by Interferon and has potent chemoattractant activity for IL-2 activated T cells, but not for freshly isolated unstimulated T cells, neutrophils, or monocytes.

• Synonyms:

  CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

• NCBI Gene ID:

  6373

• UniProt:

  O14625

• Accession Number:

  NP_005400.1

• Accession Number mRNA:

  NM_005409.4

• Chromosomal Location:

  4q21.2

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Mouse, Rabbit, Human, Monkey

• Sequence:

  FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract IL-2 activated T-cells using a concentration range of 0.1-10.0 ng/ml.

• Length:

  73

• Form:

  Lyophilized

• Molecular Weight:

  8.3 kDa

• Host or Source:

  E. coli