ApoA-I

CAT: 0209-100-123-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-123-L250Size:250 µg
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Description
ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano) . The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.
Synonyms
APOA1, Apolipoprotein A-I
NCBI Gene ID
335
UniProt
P02647
Accession Number
NP_000030.1
Accession Number mRNA
NM_000039.1
Chromosomal Location
11q23-q24
Reactivity
Human
Cross Reactivity
Hamster, Human
Sequence
MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 97% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
244
Form
Lyophilized
Molecular Weight
28.2 kDa
Host or Source
E. coli

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