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IL-36 alpha (IL-1F6)

CAT: 0209-100-160-L100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-160-L100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9) . IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein) . IL-36α also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36α is a 17.2 kDa protein containing 154 amino acid residues.
Synonyms
Interleukin-36α, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1ε (FIL1E), Interleukin-1ε (IL1E)
NCBI Gene ID
27179
UniProt
Q9UHA7
Accession Number
NP_055255.1.
Accession Number mRNA
NM_014440.2
Reactivity
Human
Cross Reactivity
Human
Sequence
MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>985 by SDS-PAGE and HPLC analyses
Bioactivity
Measured by its ability to inhibit secretion of IL-8 by A431 cells in the prescence of IL-36γ.
Length
313
Form
Lyophilized
Molecular Weight
40 kDa
Host or Source
E. coli

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