IL-36 gamma (IL-1F9)

• Description:

  The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9) . IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

• Synonyms:

  IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2

• NCBI Gene ID:

  56300

• UniProt:

  Q9NZH8

• Accession Number:

  NP_062564.1

• Accession Number mRNA:

  NM_019618.3

• Chromosomal Location:

  2q12-q21

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to induce IL-8 production by human PBMCs.

• Length:

  152

• Form:

  Lyophilized

• Molecular Weight:

  17 kDa

• Host or Source:

  E. coli