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IL-36 alpha

CAT: 0209-103-M542Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M542Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9) . IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein) . IL-36α also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36α is a 17.2 kDa protein containing 154 amino acid residues.
Synonyms
Interleukin-36α, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1ε (FIL1E), Interleukin-1ε (IL1E)
NCBI Gene ID
27179
UniProt
Q9UHA7
Accession Number
NP_055255.1.
Accession Number mRNA
NM_014440.2
Reactivity
Anti-Mouse
Cross Reactivity
Human
Target Antigen
Recombinant Mouse IL-36 alpha
Clone
(#11G13)
Applications
N/B
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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