IL-1F6

CAT: 0209-101-M497Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M497Size:100 µg
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Description
The IL-1 family of cytokines is a set of structurally related molecules that are primary mediators of inflammation. This family now consists of 11 cytokines and 9 cell-surface receptors, the best characterized of which are IL-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), and IL-18. Seven novel members were recently identified from DNA databases almost simultaneously by several different groups, and to reduce confusion, a systematic nomenclature was proposed. IL-1F6, IL-1F8, and IL-1F9 have all reported proinflammatory properties. IL-1F5 shares 52% amino acid similarity with IL-1ra and as such antagonizes IL-1F6 and IL-1F9 at the IL-1R3 (RAcP) –IL-1R6 (Rrp2) receptor complex. IL-1F7 acts as an attenuator of IL-18 activity and may act as an inhibitor of innate immune signaling.
Synonyms
IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1 (EPSILON) ; FIL1 (EPSILON)
NCBI Gene ID
27179
UniProt
Q9UHA7
Accession Number
NP_055255.1
Accession Number mRNA
NM_014440.1
Chromosomal Location
2q12-q14.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-1F6
Clone
(#3C55)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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