IL-1F6

• Description:

  The IL-1 family of cytokines is a set of structurally related molecules that are primary mediators of inflammation. This family now consists of 11 cytokines and 9 cell-surface receptors, the best characterized of which are IL-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), and IL-18. Seven novel members were recently identified from DNA databases almost simultaneously by several different groups, and to reduce confusion, a systematic nomenclature was proposed. IL-1F6, IL-1F8, and IL-1F9 have all reported proinflammatory properties. IL-1F5 shares 52% amino acid similarity with IL-1ra and as such antagonizes IL-1F6 and IL-1F9 at the IL-1R3 (RAcP) –IL-1R6 (Rrp2) receptor complex. IL-1F7 acts as an attenuator of IL-18 activity and may act as an inhibitor of innate immune signaling.

• Synonyms:

  IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1 (EPSILON) ; FIL1 (EPSILON)

• NCBI Gene ID:

  27179

• UniProt:

  Q9UHA7

• Accession Number:

  NP_055255.1

• Accession Number mRNA:

  NM_014440.1

• Chromosomal Location:

  2q12-q14.1

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human IL-1F6

• Clone:

  (#3C55)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2