IL-20

• Description:

  IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-alpha and type II IL-20R-beta. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.

• Synonyms:

  IL20; IL-20; IL10D; ZCYTO10

• NCBI Gene ID:

  50604

• UniProt:

  Q9NYY1

• Accession Number:

  NP_061194.2

• Accession Number mRNA:

  NM_018724

• Chromosomal Location:

  1q32

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to activate STAT following receptor ligand interaction.

• Length:

  153

• Form:

  Lyophilized

• Molecular Weight:

  35.2 kDa

• Host or Source:

  E. coli