CCL-20

CAT: 0209-101-M264Size: 50 µgDry Ice: NoHazardous: No

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CAT#:0209-101-M264Size:50 µg

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Description

CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is one of many novel β chemokines identified through bioinformatics. CCL20 cDNA encodes a 96 amino acid (aa) residue precursor protein with a 26 aa residue signal peptide that is predicted to be cleaved to form the 70 aa residue mature secreted protein. CCL20 is distantly related to other β chemokines (20-28% aa sequence identity) and the gene for CCL20 has been mapped to chromosome 2 rather than 17. CCL20 has been shown to be expressed predominantly in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. The expression of CCL20 is strongly upregulated by inflammatory signals and downregulated by the anti-inflammatory cytokine IL10. Synthetic or recombinant CCL20 has been shown to be chemotactic for lymphocytes and to inhibit proliferation of myeloid progenitors in colony formation assays. CCL20 has now been shown to be a unique functional ligand for CCR6 (previously referred to as GPRCY4, CKRL3, or STRL22 orphan receptor), a chemokine receptor that is selectively and highly expressed in human dendritic cells derived from CD34+ cord blood precursors.

Synonyms

CCL20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20

NCBI Gene ID

6364

UniProt

P78556

Accession Number

NP_004582

Accession Number mRNA

NM_004591

Chromosomal Location

2q33-q37

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human CCL-20

Clone

(#3K21)

Applications

WB, N

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG1

UniProtKB · P78556

C-C motif chemokine 20

CCL20_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P78556
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CCL20
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q53S51, Q99664

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

AntibioticAntimicrobialCytokine

Biological process

ChemotaxisInflammatory response

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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Alternative Products

Catalog	Name
216195	CCL-20 (Chemokine C-C Motif Ligand 20)
216196	CCL-20 (MIP-3a, Chemokine C-C Motif Ligand 20)
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GTR17975120	Ccl Antibody
hAP-5706	Sheep Polyclonal anti-Human CCL-20 (MIP-3 alpha)
GTR18090664	Mouse Monoclonal human CCL-20 (MIP-3 alpha) Antibody
mAP-0173	Rat Monoclonal anti-mouse CCL-20 (MIP-3 alpha)
GTR18090036	Rat Monoclonal mouse CCL-20 (MIP-3 alpha) Antibody
hAP-0145	Mouse Monoclonal anti-human CCL-20 (MIP-3 alpha)
hAP-0138	Human CCL-14