FGF-20

• Description :

  FGF-20 is secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-20 signals through the FGFR 2c and 3c and is expressed during limb and brain development. Recombinant human FGF-20 is a 23.2 kDa protein containing 209 amino acid residues.

• Synonyms :

  FGF20; FGF-20

• NCBI Gene ID :

  26281

• UniProt :

  Q9NP95

• Accession Number :

  NP_062825.1

• Accession Number mRNA :

  NM_019851

• Chromosomal Location :

  8p22

• Reactivity :

  Human

• Cross Reactivity :

  Monkey, Mouse

• Sequence :

  PLAEVGGFLG GLEGLGQQVG SHFLLPPAGE RPPLLGERRS AAERSARGGP GAAQLAHLHG ILRRRQLYCR TGFHLQILPD GSVQGTRQDH SLFGILEFIS VAVGLVSIRG VDSGLYLGMN DKGELYGSEK LTSECIFREQ FEENWYNTYS SNIYKHGDTG RRYFVALNKD GTPRDGARSK RHQKFTHFLP RPVDPERVPE LYKDLLMYT

• Assay Protocol :

  Reconstitute in 10mM Tris, pH 7.6, to a concentration of 0.1-1.0 mg/ml

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 90% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

• Length :

  209

• Form :

  Lyophilized

• Buffer :

  25mM Tris, pH 7.6 + 1.5M NaCl

• Reconstitution :

  25mM Tris, pH 7.6

• Molecular Weight :

  23.2 kDa

• Host or Source :

  E. coli