IL-19

• Description:

  IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.

• Synonyms:

  IL19; MDA1; NG.1; ZMDA1; IL-10C

• NCBI Gene ID:

  29949

• UniProt:

  Q9UHD0

• Accession Number:

  NP_715639.1

• Accession Number mRNA:

  NM_153758

• Chromosomal Location:

  1q32.2

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 99% by SDS-PAGE & HPLC analysis

• Bioactivity:

  Determined by its ability to activate STAT following receptor-ligand interaction.

• Length:

  153

• Form:

  Lyophilized

• Molecular Weight:

  17.9 kDa

• Host or Source:

  E. coli