ADAM-19

• Description:

  ADAM-19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrinβ) is a 95-100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to α2 Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin β chain, TNFα, TRANCE and SCF. Over amino acids (aa) 205-705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

• Synonyms:

  Adam19; M[b]; Mltnb; AL024287

• NCBI Gene ID:

  11492

• UniProt:

  O35674

• Accession Number:

  NP_033746.1

• Accession Number mRNA:

  NM_009616

• Chromosomal Location:

  11 A5-B1.1; 11 20.0 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant protein of A Disintegrin and Metalloprotease-like Domain 19 ectodomain

• Clone:

  (#11J23)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Bioactivity:

  WB: 1:500-1000.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2