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FGF-19

CAT: 0209-101-M725Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M725Size:50 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human FGF19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites. Among FGF family members, human FGF19 is most closely related to chicken FGF19 and murine FGF15, sharing approximately 61% and 51% aa sequence identity, respectively. Neither the human orthologue of mouse FGF15, nor the mouse counterpart of human FGF19 has been identified. With the exception of adult gall bladder epithelium, FGF19 expression is restricted to fetal tissues. Unlike most FGFs which bind to and activate more than one FGF receptor, FGF19 is a specific ligand for FGF R4. Similarly, another FGF family member, FGF7 (KGF), only activates KGF R, the IIIb isoform of FGF R2. During chick embryogenesis, FGF19 has been shown to act synergistically with Wnt8c to initiate inner ear development.
Synonyms
FGF19
NCBI Gene ID
9965
UniProt
O95750
Accession Number
NP_005108.1
Accession Number mRNA
NM_005117
Chromosomal Location
11q13.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human FGF-19
Clone
(#4G89)
Applications
WB, N, Capture Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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