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IL-12

CAT: 0209-M10-021-L50Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-M10-021-L50Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.
Synonyms
NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF
NCBI Gene ID
P35: 16159; p40: 16160
UniProt
P35: P43431; p40: P43432
Accession Number
P35: NP_001152896.1; p40: NP_001290173.1
Accession Number mRNA
P35: NM_001159424.2; p40: NM_001303244.1
Chromosomal Location
3 E1; 3 37.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
P35 Subunit: RVIPVSGPAR CLSQSRNLLK TTDDMVKTAR EKLKHYSCTA EDIDHEDITR DQTSTLKTCL PLELHKNESC LATRETSSTT RGSCLPPQKT SLMMTLCLGS IYEDLKMYQT EFQAINAALQ NHNHQQIILD KGMLVAIDEL MQSLNHNGET LRQKPPVGEA DPYRVKMKLC ILLHAFSTRV VTINRVMGYL SSA p40 Subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to induce cell proliferation in T-cell enriched PBMCs. The expected ED50 is ≤0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Length
506
Form
Lyophilized
Molecular Weight
75 kDa
Host or Source
CHO cells

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