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MMP-12

CAT: 0209-101-M114Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M114Size:100 µg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMP12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, α-1antitrypsin, and plasminogen. It can also activate MMP2 and MMP-3. The MMP12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin like domain.
Synonyms
MMP12; ME; HME; MME; MMP-12
NCBI Gene ID
4321
UniProt
P39900
Accession Number
NP_002417.2
Accession Number mRNA
NM_002426.4
Chromosomal Location
11q22.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human MMP-12
Clone
(#7G20)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: Use at 1:500-2000; IHC: 1:50-300
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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