FGF-12

• Description :

  FGF-12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn’t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF-12 accumulated in the nucleus, but was not secreted. FGF-12 is involved in nervous system development and function. FGF-12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange. FGF-12 is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6 kDa and containing 201 amino acids (1-181) . The FGF12 is fused to a 20 amino acid His tag at the N-terminus.

• Synonyms :

  FGF12; FHF1; FGF12B

• NCBI Gene ID :

  2257

• UniProt :

  P61328

• Accession Number :

  NP_066360

• Accession Number mRNA :

  NM_021032

• Chromosomal Location :

  3q28

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Label :

  His-Tag

• Sequence :

  MSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE YLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR RKSSGTPTM NGGKVVNQDS T

• Purity :

  > 90% by SDS-PAGE

• Length :

  201

• Form :

  Liquid

• Buffer :

  20mM Tris pH-7.5, 1mM DTT, 2mM EDTA and 10% glycerol.

• Molecular Weight :

  22.6 kDa

• Host or Source :

  E. coli