IL-1 alpha

CAT: 0209-100-042-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-100-042-L100Size:100 µg
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Description
IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
Synonyms
IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA
NCBI Gene ID
3552
UniProt
P01583
Accession Number
NP_000566.3
Accession Number mRNA
NM_000575
Chromosomal Location
2q14
Reactivity
Human
Cross Reactivity
Cow, Monkey, Mouse, Human, Frog, Pig
Sequence
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
Length
159
Form
Lyophilized
Molecular Weight
18 kDa
Host or Source
E. coli

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