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IFN lambda1 (IL-29)

CAT: 0209-100-193-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-193-L250Size:250 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IFN lambda-1, -2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defense similar but distinct than the type I interferons (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77) . Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.
Synonyms
IL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B
NCBI Gene ID
282618
UniProt
Q8IU54
Accession Number
NP_742152.1
Accession Number mRNA
NM_172140.1
Chromosomal Location
19q13.13
Reactivity
Human
Cross Reactivity
Human, Monkey
Sequence
PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Length
178
Form
Lyophilized
Molecular Weight
19.8 kDa
Host or Source
E. coli

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