IFN lambda-2 (IL-28A)

• Description:

  Human/mouse IFN-lambda 2 or IL-28A, IL-28B (or IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity) . These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1) . Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

• Synonyms:

  Il28a; Ifnl2; IL-28A; EG330496

• NCBI Gene ID:

  330496

• UniProt:

  Q4VK74

• Accession Number:

  NP_00109844.2

• Accession Number mRNA:

  NM_001024673

• Chromosomal Location:

  7 A3; 7

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Virus

• Sequence:

  MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKA KDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to activate STAT following receptor-ligand interaction.

• Length:

  175

• Form:

  Lyophilized

• Molecular Weight:

  19.8 kDa

• Host or Source:

  E. coli