IFN lambda2 (IL-28A)

• Description :

  IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant murine IFN-lambda2 is a 19.8 kDa protein containing 175 amino acid residues.

• Synonyms :

  IL28A; IFNL2; IL-28A

• NCBI Gene ID :

  282616

• UniProt :

  Q8IZJ0

• Accession Number :

  NP_742150.1

• Accession Number mRNA :

  NM_172138

• Chromosomal Location :

  19q13.13

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  PVARLHGALP DARGCHIAQF KSLSPQELQA FKRA KDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.

• Length :

  174

• Form :

  Lyophilized

• Molecular Weight :

  19.6 kDa

• Host or Source :

  E. coli