GH1 Protein

• Description:

  Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones-GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin and leptin. The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified.

• Synonyms:

  GH Protein; GH-N Protein; GHB5 Protein; GHN Protein; hGH-N Protein; IGHD1A Protein; IGHD1B Protein; IGHD2 Protein

• Accession Number:

  P01241

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Assay Protocol:

  See Datasheet send with the product

• Endotoxin:

  Please contact us for more information.

• Purity:

  ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

• Bioactivity:

  Measured by its ability to induce GH pathway activation in a Luciferase receptor Assay System. The ED50 for this effect is 3-25 ng/mL.

• Length:

  191

• Form:

  Lyophilized

• Buffer:

  PBS, pH 7.4

• Reconstitution:

  See Datasheet

• Molecular Weight:

  22.1 kDa

• Storage Conditions:

  Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• Host or Source:

  E.coli