FGF-8a

• Description:

  FGF-8 is a heparin-binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. There are 4 known alternate spliced forms of FGF8; FGF-8a, FGF-8b, FGF-8e and FGF-8f. The human and murine FGF-8a and FGF-8b are identical, unlike human and mouse FGF-8e and FGF-8f, which are 98% identical. FGF-8 targets mammary carcinoma cells and other cells expressing the FGF receptors. CHO cell-derived recombinant human FGF-8a is a 21.2 kDa protein consisting of 182 amino acid residues.

• Synonyms:

  Fibroblast Growth Factor-8, FGF-8a, AIGF, HBGF-8

• NCBI Gene ID:

  2253

• UniProt:

  P55075-2

• Accession Number:

  NP_149355.1

• Accession Number mRNA:

  NM_033165.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  QHVREQSLVT DQLSRRLIRT YQLYSRTSGK HVQVLANKRI NAMAEDGDPF AKLIVETDTF GSRVRVRGAE TGLYICMNKK GKLIAKSNGK GKDCVFTEIV LENNYTALQN AKYEGWYMAF TRKGRPRKGS KTRQHQREVH FMKRLPRGHH TTEQSLRFEF LNYPPFTRSL RGSQRTWAPE PR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by a cell proliferation assay using balb/c 3T3 cells.

• Length:

  182

• Form:

  Lyophilized

• Molecular Weight:

  21.2 kDa

• Host or Source:

  CHO cells