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Wnt-8a

CAT: 0209-103-M503Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M503Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wnt-8a is a secreted glycoprotein that binds to receptors of the Frizzled family. Wnt-8a is expressed during early optic lens development and cardiac myogenesis. The expression of Wnt-8a has also been shown to be upregulated during primitive hematopoiesis. TGF-beta has been shown to increase Wnt-8a secretion during epithelial mesenchymal transition (EMT) . The Wnts make up a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt family members vary in length between 350 and 400 amino acids (aa), possess 22 to 24 conserved cysteines, are highly hydrophobic, and show 20 - 85% aa identity within the Wnt family. In general, there are three signaling pathways associated with Wnt-receptor interaction. The first is commonly called the canonical pathway and ultimately culminates in beta-Catenin accumulation and TCF/LEF-1-mediated gene transcription. The other two less well-defined non-canonical pathways include the Wnt/Ca2+ pathway and the planar cell polarity (PCP) pathway.
Synonyms
WNT8A; WNT8D
NCBI Gene ID
7478
UniProt
Q9H1J5
Accession Number
NP_490645.1
Accession Number mRNA
NM_058244
Chromosomal Location
5q31
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant protein Wnt-8a
Clone
(#38L1)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

UniProtKB · Q9H1J5

Protein Wnt-8a

WNT8A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H1J5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
WNT8A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D6RF47, Q96S51
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Developmental protein

PTM

Disulfide bondGlycoproteinLipoprotein

Cellular component

Extracellular matrixSecreted

Domain

Signal

Biological process

Wnt signaling pathway

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Alternative Products

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sc-72396-PRWnt-8a (h) -PR
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8419-WN-010Recombinant Mouse Wnt-8a
sc-72396Wnt-8a siRNA (h)
sc-72397Wnt-8a siRNA (m)
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