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GDF-5 Recombinant Protein

CAT: 0223-40-579-01Size: 0.01 mgDry Ice: NoHazardous: No
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CAT#:0223-40-579-01Size:0.01 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
NCBI Gene ID
8200
Swiss Prot
P43026
Accession Number
NP_000548.1
Type
Recombinant Proteins
Source
E. coli
Field of Research
Growth Factors, Signal Transduction
Purity
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Shipping Conditions
Room Temp
Storage Conditions
The lyophilized GDF-5 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted GDF-5 stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing GDF-5 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
NCBI Official Name
Growth differentiation factor 5
NCBI Organism
Homo sapiens
Other Product Names
OS5, LAP4, BDA1C, BMP14, CDMP1, SYM1B, SYNS2, Cartilage-derived morphogenetic protein 1, GDF-5
Species
Murine
Protein ID
4503969
Physical Properties
Lyophilized

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