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CD163 Antibody

CAT: 0223-62-830Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-830Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
NCBI Gene ID
9332
Swiss Prot
Q86VB7
Accession Number
Q86VB7
Host
Rabbit
Reactivity
Human
Immunogen
This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
125 kDa
Fragment
Rabbit Ig
Symbol
CD163
NCBI Official Name
Scavenger receptor cysteine-rich type 1 protein M130
NCBI Organism
Homo sapiens
Background Reference 01
Buehler, P.W., Abraham, B. Blood 113 (11), 2578-2586 (2009)
Background Reference 02
Fabriek, B.O., van Bruggen, R. Blood 113 (4), 887-892 (2009)
Background Reference 03
Strauss, M. and Levy, A.P. Mol. Cell. Biochem. 317 (1-2), 131-135 (2008)
Background Reference 04
Groselj-Grenc, M., Ihan, A. Mediators Inflamm. 2008, 202646 (2008)
Other Product Names
Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130
Tested Applications
WB, IHC-P
Protein ID
313104083
Physical Properties
Liquid

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