CD163 Antibody

• Background :

  CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

• NCBI Gene ID :

  9332

• Swiss Prot :

  Q86VB7

• Accession Number :

  Q86VB7

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  125 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CD163

• NCBI Official Name :

  Scavenger receptor cysteine-rich type 1 protein M130

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Buehler, P.W., Abraham, B. Blood 113 (11), 2578-2586 (2009)

• Background Reference 02 :

  Fabriek, B.O., van Bruggen, R. Blood 113 (4), 887-892 (2009)

• Background Reference 03 :

  Strauss, M. and Levy, A.P. Mol. Cell. Biochem. 317 (1-2), 131-135 (2008)

• Background Reference 04 :

  Groselj-Grenc, M., Ihan, A. Mediators Inflamm. 2008, 202646 (2008)

• Other Product Names :

  Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130

• Tested Applications :

  WB, IHC-P

• Protein ID :

  313104083

• Physical Properties :

  Liquid