Cyclin D1 (phospho Ser90) Antibody

• Background:

  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

• NCBI Gene ID:

  595

• Swiss Prot:

  P24385

• Accession Number:

  NP_444284.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Cyclin D1 (phospho Ser90) antibody was raised against a peptide sequence around phosphorylation site of serine 90 (F-L-S (p) -L-E) derived from Human Cyclin D1 .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous level of Cyclin D1 only when phosphorylated at serine 90.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  CCND1

• NCBI Official Name:

  Cyclin D1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sewing A, Müller R (1994) Oncogene 9, 2733-6

• Other Product Names:

  BCL1, CCND1, CYL-1, PRAD1, PRAD1 oncogene

• Tested Applications:

  WB

• Protein ID:

  116152

• Physical Properties:

  Liquid