SREBP-1 (phospho Ser439) Antibody

• Background:

  Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway By similarity. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') . Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') .

• NCBI Gene ID:

  6720

• Swiss Prot:

  P36956

• Accession Number:

  NP_001005291.1

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  SREBP-1 (phospho Ser439) antibody was raised against a peptide sequence around phosphorylation site of serine439 (Q-S-S (p) -P-L) derived from Human SREBP-1 .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  122 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous level of SREBP-1 only when phosphorylated at serine 439.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  SREBF1

• NCBI Official Name:

  Sterol regulatory element binding transcription factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bengoechea-Alonso MT, Ericsson J (2006) Cell Cycle 5, 1708-18

• Other Product Names:

  SRBP1, SREBF1, SREBP1, sterol regulatory element-binding protein 1

• Tested Applications:

  WB

• Protein ID:

  52630419

• Physical Properties:

  Liquid