HDAC3 Antibody

CAT: 0223-79-759Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-759Size:0.1 mg
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Background
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation
NCBI Gene ID
8841
Swiss Prot
O15379
Accession Number
NP_003874.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
HDAC3 antibody was raised against a peptide sequence around aa.420~424 (N-D-K-E-S) derived from Human HDAC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
49 kDa
Specificity
This antibody detects endogenous level of total HDAC3 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
HDAC3
NCBI Official Name
Histone deacetylase 3
NCBI Organism
Homo sapiens
Other Product Names
HD3, RPD3, RPD3-2, HD3
Tested Applications
WB
Protein ID
13128862
Physical Properties
Liquid

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