HDAC3 Antibody

• Background:

  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation

• NCBI Gene ID:

  8841

• Swiss Prot:

  O15379

• Accession Number:

  NP_003874.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  HDAC3 antibody was raised against a peptide sequence around aa.420~424 (N-D-K-E-S) derived from Human HDAC3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  49 kDa

• Specificity:

  This antibody detects endogenous level of total HDAC3 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  HDAC3

• NCBI Official Name:

  Histone deacetylase 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  HD3, RPD3, RPD3-2, HD3

• Tested Applications:

  WB

• Protein ID:

  13128862

• Physical Properties:

  Liquid