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MEK5 Antibody

CAT: 0223-79-696Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-696Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A family of protein kinases located upstream of the MAP kinases andresponsible for their activation has been identified. The prototype member ofthis family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present inthe Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to acti-vate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activatesboth p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.
NCBI Gene ID
29568
Swiss Prot
Q62862
Accession Number
NP_001029159.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MEK5 antibody was raised against a peptide sequence around aa. 311-315 (K-T-Y-V-G) derived from Rat MEK5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
49 kDa
Specificity
This antibody detects endogenous level of total MEK5 protein.
Applications Notes
Western Blot: 1:500
Symbol
Map2k5
NCBI Official Name
Mitogen activated protein kinase kinase 5
NCBI Organism
This antibody was raised against a peptide sequence around aa. 311-315 (K-T-Y-V-G) derived from Rat MEK5.
Background Reference 01
Han, J., et al. 1996. J. Biol. Chem. 271: 2886-2891. Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926. Tournier, C., et al. 1997. Proc. Natl. Acad. Sci. USA94: 7337-7442. Holland, P. M., et al. 1997. J. Biol. Chem. 272: 24994-24998.
Other Product Names
Mek5, MAP kinase kinase 5, Map2k5, MAPKK 5, MAPK/ERK kinase 5
Tested Applications
WB
Protein ID
77157802
Physical Properties
Liquid

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