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MEK3 Antibody

CAT: 0223-63-285Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-285Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.
NCBI Gene ID
5606
Swiss Prot
P46734
Accession Number
P46734
Host
Rabbit
Reactivity
Human
Immunogen
This MEK3 (MAP2K3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human MEK3 (MAP2K3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Symbol
MAP2K3
NCBI Official Name
Dual specificity mitogen-activated protein kinase kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Yustein, J.T., et al., Oncogene 22 (40) :6129-6141 (2003) .
Background Reference 02
Edlund, S., et al., Mol. Biol. Cell 14 (2) :529-544 (2003) .
Background Reference 03
Lim, S., et al., J. Biol. Chem. 277 (28) :25040-25046 (2002) .
Background Reference 04
Han, Q., et al., J. Biol. Chem. 277 (50) :48379-48385 (2002) .
Other Product Names
Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Tested Applications
WB, IHC-P
Protein ID
24638466
Physical Properties
Liquid

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