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Lin28 Antibody

CAT: 0223-79-647Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-647Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.
NCBI Gene ID
79727
Swiss Prot
Q9H9Z2
Accession Number
NP_078950.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Lin28 antibody was raised against a peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28 .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
26 kDa
Specificity
This antibody detects endogenous levels of total Lin28 protein.
Applications Notes
Western Blot: 1:1000
Symbol
LIN28A
NCBI Official Name
Lin-28 homolog A (C. elegans)
NCBI Organism
Homo sapiens
Background Reference 01
Heo I., Joo C., Mol. et al., Cell 32:276-284 (2008) Heo I., Joo C., Kim Y. -K., et al., Cell 138:696-708 (2009) Viswanathan S. R., Powers J. T., et al., Nat. Genet. 41:843-848 (2009)
Other Product Names
CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A, CSDD1, LIN28A
Tested Applications
WB
Protein ID
13375938
Physical Properties
Liquid

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