LIN28B Antibody

• Background :

  Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

• NCBI Gene ID :

  389421

• Swiss Prot :

  Q6ZN17

• Accession Number :

  Q6ZN17

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This LIN28B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-128 amino acids from the Central region of human LIN28B.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  27 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  LIN28B

• NCBI Official Name :

  Protein lin-28 homolog B

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Guo, Y., Gene 384, 51-61 (2006)

• Other Product Names :

  Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2

• Tested Applications :

  WB, IHC-P, IF, Flow

• Protein ID :

  74758701

• Physical Properties :

  Liquid