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P53 (Ab 46) Antibody

CAT: 0223-79-534Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-534Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.
NCBI Gene ID
7157
Swiss Prot
P04637
Accession Number
NP_000537.3
Host
Rabbit
Reactivity
Human
Immunogen
P53 (Ab-46) antibody was raised against a peptide sequence around aa. 44~48 (M-L-S-P-D) derived from Human p53.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
53 kDa
Specificity
This antibody detects endogenous level of total p53 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
TP53
NCBI Official Name
Tumor protein p53
NCBI Organism
Homo sapiens
Background Reference 01
Dhavan, R. and Tsai, L. H. (2001) Nat Rev Mol Cell Biol. 2: 749-759. Patrick, G. N. et al. (1998) J Biol Chem. 273: 24057-24064. Di Stefano V, et al. (2005) Oncogene. 24 (35) : 5431-5442. Mayo LD, et al. (2005) J Biol Chem. 280 (28) : 25953-25959. Wang L, et al. (2005) Oncogene. 24 (18) : 3020-3027.
Other Product Names
P53, BCC7, LFS1, TRP53, CD49D, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
Tested Applications
WB
Protein ID
120407068
Physical Properties
Liquid

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