Products for Research Use Only
RegisterLogin

P53 (Ab 9) Antibody

CAT: 0223-79-530Size: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-79-530Size:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
P53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes
NCBI Gene ID
7157
Swiss Prot
P04637
Accession Number
NP_000537.3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
P53 (Ab-9) antibody was raised against a peptide sequence around aa.7~11 (D-P-S-V-E) derived from Human p53.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
53 kDa
Specificity
This antibody detects endogenous level of total p53 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
TP53
NCBI Official Name
Tumor protein p53
NCBI Organism
Homo sapiens
Background Reference 01
Ito, A. et al. (2001) EMBO J. 20, 1331-1340. Sakaguchi, K. et al. (1998) Genes Dev. 12, 2831-2841. Solomon, J. M. et al. (2006) Mol. Cell. Biol. 26, 28-38.
Other Product Names
P53, BCC7, LFS1, TRP53, Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13, TP53
Tested Applications
WB
Protein ID
120407068
Physical Properties
Liquid

Related Products

CatalogName
79-318P53 (Ab 15) Antibody
79-534P53 (Ab 46) Antibody
79-529P53 (Ab 6) Antibody
79-600Synapsin (Ab 9) Antibody
79-253GSK3beta (Ab 9) Antibody
99-035I-Ab Antibody [25-9-3]
99-037I-Ab Antibody [25-9-3] (PE)
99-036I-Ab Antibody [25-9-3] (Biotin)
33-706P53 Antibody
18-984P53 Antibody

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
DF8746-01ASAP1 antibody Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products