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P53 Antibody

CAT: 0223-62-206Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-206Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
NCBI Gene ID
7157
Swiss Prot
P04637
Accession Number
P04637
Host
Rabbit
Reactivity
Human
Immunogen
This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-385 amino acids from the C-terminal region of human p53.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000-1:2000
Symbol
TP53
NCBI Official Name
Cellular tumor antigen p53
NCBI Organism
Homo sapiens
Background Reference 01
Blanchette, P., et al., Mol. Cell. Biol. 24 (21) :9619-9629 (2004) .
Background Reference 02
Adachi, K., et al., Oncogene 23 (47) :7791-7798 (2004) .
Background Reference 03
Zhang, Y., et al., J. Biol. Chem. 279 (41) :42545-42551 (2004) .
Background Reference 04
Anazawa, Y., et al., Oncogene 23 (46) :7621-7627 (2004) .
Other Product Names
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Tested Applications
WB
Protein ID
269849759
Physical Properties
Liquid

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