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P53 Antibody

CAT: 0223-61-402Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-402Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. P53 is subject to modification by conjugation of SUMO-1. A p53 mutant deficient for MDM2 binding is poorly sumoylated in vivo compared to wild-type p53. Overexpression of MDM2 increases the level of p53 sumoylation, which is further stimulated by expression of ARF. These results show that p53 sumoylation is regulated by MDM2- and ARF-mediated nucleolar targeting.
NCBI Gene ID
7157
Swiss Prot
P04637
Accession Number
P04637
Host
Rabbit
Reactivity
Human
Immunogen
This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from human p53.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
TP53
NCBI Official Name
Cellular tumor antigen p53
NCBI Organism
Homo sapiens
Background Reference 01
Chen L, et al. Oncogene. 2003 Aug 14;22 (34) :5348-57.
Background Reference 02
Melchior F, et al. Cell Cycle. 2002 Jul-Aug;1 (4) :245-9.
Background Reference 03
Kahyo T, et al. Mol Cell. 2001 Sep;8 (3) :713-8.
Background Reference 04
Kwek SS, et al. Oncogene. 2001 May 3;20 (20) :2587-99.
Other Product Names
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
Tested Applications
WB, IHC-P
Protein ID
269849759
Physical Properties
Liquid

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