CD273 Antibody [TY25]

The TY25 antibody reacts with mouse B7-DC (PD-L2), a 42 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. B7-DC is expressed by macrophages, monocytes, and sub-populations of dendritic cells. B7-DC has similarities with the rest of the B7 family, but it does not bind to CD28/CD152. The receptor for B7-DC is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between B7-DC and its receptor seems to downregulate immune responses. However, B7-DC seems to be a costimulator of T lymphocytes, reacting with a receptor different than PD-1. B7-DC can bind and stimulate dendritic cells. It is also the first B-7 ligand involved in bidirectional communication. The TY25 monoclonal antibody blocks the binding of B7-DC to its receptor (PD-1) and can be used for studying the interaction between the antigen presenting cells and T lymphocytes.

58205

Q9WUL5

Mouse

TY25

Unconjugated

Primary Antibodies

Innate Immunity, Immunology

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Batch dependent

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

None

Blue Ice

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Rat IgG2a, kappa

The TY25 antibody reacts with mouse B7-DC (PD-L2), a 42 kDa glycoprotein of the B7 family of the immunoglobulin superfamily.

Pdcd1lg2

Programmed cell death 1 ligand 2

Mus musculus

Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., Seya, T. (2002) . Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.Biochemical and biophysical research communications,293 (5), 1364-1369.

Schreiner, B., Voss, J., Wischhusen, J., Dombrowski, Y., Steinle, A., Lochm, H., ... Wiendl, H. (2006) . Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands.The FASEB journal,20 (1), 118-120.

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T. (2003) . TICAM-1, an adaptor molecule that participates in Toll-like receptor 3mediated interferon--beta- induction.Nature immunology,4 (2), 161-167.

Btdc, B7-DC, PD-L2, F730015O22Rik, Pdcd1lg2

Flow, Functional Assays, IHC, IF, IP, WB